Research
In neurons, endoplasmic reticulum (ER) is not only found in the cell body, but also extends into dendrites and axonal presynaptic terminals. Axonal ER comprises a tubular network of mainly smooth ER, whose function is still poorly understood. In humans, mutations of several axonal ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease.
Using Drosophila as model system, we try to understand the functional consequences of disrupting the axonal ER presence or continuity.
Publications
Pérez-Moreno JJ, Smith RC, Oliva MK, Gallo F, Ojha S, Müller KH, O'Kane CJ (2023) Drosophila SPG12 ortholog, reticulon-like 1, governs presynaptic ER organization and Ca2+ dynamics. J Cell Biol. 2023 Jun 5;222(6):e202112101
Pérez-Moreno JJ, Santa-Cruz Mateos C, Martín-Bermudo MD, Estrada B (2022) LanB1 Cooperates With Kon-Tiki During Embryonic Muscle Migration in Drosophila. Front Cell Dev Biol. 2022 Jan 3;9:749723. doi: 10.3389/fcell.2021.749723.
Oliva MK, Pérez-Moreno JJ, O'Shaughnessy J, Wardill TJ, O'Kane CJ (2020) Endoplasmic reticulum (ER) lumenal indicators in Drosophila reveal effects of HSP-related mutations on ER calcium dynamics. Frontiers in Neuroscience 14:816
Öztürk Z, O’Kane CJ and Pérez-Moreno JJ (2020) Axonal Endoplasmic Reticulum Dynamics and Its Roles in Neurodegeneration. Frontiers in Neuroscience 14:48
Pérez-Moreno JJ, O'Kane CJ (2019) GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila. G3: Genes, Genomes, Genetics 9(2):453-462
Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B (2017) Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction. Journal of Cell Science 130(5):950-962
Pérez-Moreno JJ, Bischoff M, Martín-Bermudo MD, Estrada B (2014) The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila. Journal of Cell Science 127(14):3162-73
