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Shaping up : Two papers in 'Development' from the Martinez Arias Group

last modified Nov 06, 2014 09:07 AM
Members of the Martinez Arias Lab in the Department of Genetics have been able to reconstruct the early stage of mammalian development using embryonic stem cells, showing that a critical mass of cells is needed for the cells to being self-organising into the correct structure for an embryo to form.


The research is published in two papers in 'Development':

Susanne C Van den Brink, Peter Baillie-Johnson, Tina Balayo, Anna-Katerina Hadjantonakis, Sonja Nowotschin, David A. Turner and Alfonso Martinez Arias : Symmetry breaking, germ layer specification and axial organisation in aggregates of mouse ES cells. Development; 4 Nov 2104.
Read this OPEN ACCESS paper at : http://dev.biologists.org/content/141/22/4231.abstract

David A. Turner, Penelope C. Hayward, Peter Baillie-Johnson, Pau Rue, Rebecca Broome, Fernando Faunes and Alfonso Martinez Arias :  Wnt/β-catenin and FGF signalling direct the specification and maintenance of a neuromesodermal axial progenitor in ensembles of mouse ES cells. Development; 4 Nov 2104.
Read this OPEN ACCESS paper at : http://dev.biologists.org/content/141/22/4243.abstract

More on the University of Cambridge news pages at: http://www.cam.ac.uk/research/news/shaping-up-researchers-reconstruct-early-stages-of-embryo-development

Alfonso shaping up 475

Image : Mouse Embryonic Stem cells bearing a reporter for Wmt signalling. The left picture shows a group of ES cells displaying Wnt signalling (red)  in adherent culture, the middle one is the same cells in an elongating ‘organoid” which we call a ‘gastruloid” -notice the localized expression of the reporter-; finally the picture on the right is an embryo bearing the Wnt reporter at a stage we reckon mimics that of the aggregates in the middle. Pictures  courtesy of David Turner, Peter Baillie Johnson and Christoph Budjan. 

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