Computational and Genomics Approaches to Drosophila Transcriptional Regulation
Drosophila, transcription factors, cis-regulatory modules, gene regulation, genomics, computational biology
I have an interest in site-specific transcription factors (TFs) and their role in combinatorial gene regulation, particularly in Drosophila development. Gene activity is precisely regulated by TFs, which bind to regulatory bits of DNA forming so-called cis-regulatory modules (CRMs). These CRMs comprise defined combinations of binding sites for activating and repressing TFs. Although still enigmatic and challenging to access experimentally, I am interested in the characteristics of CRMs involved in metazoan development on the systems level.
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Please see information about my publications on the group website.