Marcin Przewloka
I graduated with MSc and PhD degrees from Warsaw University, Poland. I then moved to Los Alamos National Lab (Los Alamos, NM) and later to Albert Einstein College of Medicine (Bronx, NY) for my postdoctoral training.
I started working with David Glover's lab as a member of the Cell Cycle Proteomics Group, an initiative involving the Departments of Genetics, Biochemistry and Cambridge Centre for Proteomics. At that time the project focused on the characterization of protein complexes involved in cell cycle regulation. In the course of those studies we encountered protein complexes forming kinetochores, structures responsible for the attachment of microtubule fibers to mitotic chromosomes. Since kinetochores in Drosophila were very poorly characterized, we decided to follow up on this part of the project.
We are now trying to dissect kinetochore composition and structure, as well as interactions between the subunits comprising kinetochore multiprotein complexes. We also plan to study regulatory mechanisms that allow kinetochores to perform all their major functions, such as their proper assembly on centromeres, attachment of microtubules, and the regulation of the spindle assembly checkpoint.
Areas of interest:- Centromeres and kinetochores
- Chromosome structure
- Genomic stability
- D'Avino PP, Archambault V, Przewloka MR, Zhang W, Laue ED, Glover DM. Isolation of protein complexes involved in mitosis and cytokinesis from Drosophila cultured cells. Methods Mol Biol. 2009; 545:99-112.
- Przewloka MR, Venkei Z, Glover DM. Searching for Drosophila Dsn1 kinetochore protein. Cell Cycle. 2009; 8(8):1292-3.
- Przewloka MR, Glover DM. The kinetochore and the centromere: a working long distance relationship. Annu Rev Genet. 2009; 43:439-65.
Marcin Przewloka
Address:
Department of Genetics,
University of Cambridge,
Downing Street,
Cambridge,
CB2 3EH,
England.
Email:
mrp50@hermes.cam.ac.uk
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Information about former members of the Glover group is available.