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Examples of recent BBS Dissertation titles

Examples of dissertation titles offered 2016

  • Bacterial persisters: molecular mechanisms and clinical management
  • Can we assign a function to 80% of the DNA in the human genome?
  • The biology of CRISPR/CAS systems and their uses in eukaryotic genome engineering
  • How can genomic data be used to understand cancer evolution and to assist with cancer therapy?
  • How does a cell make a decision to divide – or stop dividing?
  • How have bdelloid rotifers avoided sex for so long?
  • Discuss the concepts presented in C H Waddington’s 1942 paper in Nature ‘Canalisation of development and the inheritance of acquired characteristics’
  • Transgenerational epigenetic inheritance in mammals - fact or fiction?
  • Many human cancers are aneuploid. Yet aneuploidy has detrimental effects on human development and has been shown to reduce cellular fitness : Consider this conundrum
  • Why do endosymbiotic bacteria have small genomes?
  • Cell and gene therapy – the future of human monogenic disorders
  • Have regulatory changes been more important for the evolution and divergence of species than changes in protein coding sequence?
  • Discuss recent developments in the mechanistic understanding of cell size control

Examples of dissertation titles offered 2015

  • Human (especially female) meiosis appears to be extraordinarily error-prone. What progress has been made in understanding this genetic problem?
  • To what extent can evolution be predicted?
  • Discuss the proposition that we can assign a function to 80% of the DNA in the human genome
  • Telomeropathies: Consider the contribution of telomere maintenance mechanisms to inherited genetic disease
  • The biology of Crispr/Cas systems and their uses in eukaryotic genome engineering
  • How can genomic data be used to understand cancer evolution and to assist with cancer therapy?
  • Transgenerational epigenetic inheritance in mammals - fact or fiction?
  • How much can we learn about essential genes from RNAi screens in worm and fly?
  • Discuss the origin and biological significance of horizontal gene transfer events in higher plants
  • Why do endosymbiotic bacteria have small genomes?
  • How does a cell make a decision to divide or stop dividing?
  • What has experimental evolution taught us about how new species arise?
  • Discuss the limitations and potential of recent developments in haploid cell genetics