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Recent titles of projects and essays


The Department offers the choice of ‘wet’ or ‘dry’ projects, which are undertaken in the Lent Term.

Examples of project titles offered 2014

  • The role of Brain Derived Neurotrophic Factor in Alzheimer's disease
  • Testing neurons for odour discrimination in larval Drosophila
  • Comparative analysis of phenotypes
  • What determines the evolutionary rates of pathogenic bacteria?
  • Sox100B target genes
  • A teaching resource for transcriptional regulation and transcription factor combinatorics
  • Tracking in vivo mobility of polarity determinants during the cell cycle
  • Indole Pulse Signalling and Stress Responses in E. coli
  • Screen for new chromatin regulators that function with heterochromatin proteins
  • Development of database mining approaches to identify new members of biological pathways
  • Maintaining ‘epigenetic’ memory - Characterisation of ZFP57 mutant mice
  • Use of photoconvertible fluorescent proteins to untangle the growth cascade of S. pombe
  • In silico characterization of mitochondrial proteins and RNAs in Drosophila
  • Mouse digestive tract development - Lineage tracing using Troy-GFP-ires-CreERT2 mouse line

Examples of project titles offered 2013

  • Generating tools for targeted expression in Drosophila inhibitory neurons
  • Evolutionary dynamics of carriage and disease in Bacteria
  • Do flies acquire immunity to viral infection?
  • Silencing of chalcone synthase (CHS) in Arabidopsis
  • Human topoisomerase 2α, SUMO and the centromere
  • What are the phenotypes of mutations in Drosophila spastic paraplegia genes?
  • Transcription factors that may regulate tissue or developmental-stage specific expression in Drosophila
  • How can we learn the most relevant functions in annotation-rich genes?
  • Protein functions in centriole biogenesis - looking for missing molecules of the jigsaw
  • Study of the variables controlling differentiation of ES cells
  • Application of in silico tools and techniques in translational research to uncover cross-species disease relationships
  • Mesodermal reporter expression in transgenic Drosophila embryos
  • What affects the rate of protein clearance in the brain?
  • Exploring the role of Miranda in asymmetric cell division

Extended Essays

An extended essay is completed over the Christmas Vacation

Examples of extended essay titles offered 2013/4

  • What can we learn from different types of biological networks using Gene Set Enrichment Analysis?
  • Discuss the methylome of higher plants
  • The limitations and potential of recent developments in haploid cell genetics
  • What has experimental evolution taught us about how new species arise?
  • In future antibiotics may be of decreasing use: Review the alternative or complementary anti-bacterial strategies that might avoid a healthcare disaster
  • How much can we trust biological databases?
  • Why do cancer cells have multiple centrosomes?
  • How have the recent findings of chromothripsis and kategis changed our view of carcinogenesis?
  • Properties and mechanisms of action of transcriptional enhancers
  • Discuss mitotic microtubule plus-end regulators in humans
  • Exploiting tumour epigenetics for cancer therapy
  • The cell cycle exit mechanism - how do cells brake division?
  • What can we learn about cell fate decisions from the analysis of single cells?
  • Is the eukaryotic genome organised into domains?

Examples of extended essay titles offered 2012/3 

  • What can we learn from different types of biological networks using Gene Set Enrichment Analysis?
  • Some higher plants have evolved the capacity to parasitise other higher plants. Discuss the interactions between these plants & hosts
  • Why do endosymbiotic bacteria have small genomes?
  • The role of centrosome deregulation in tumorigenesis & its potential as a clinical strategy to kill cancer cells by targeting centrosomes
  • Discuss the limitations and potential of recent developments in haploid cell genetics
  • Why do Y chromosomes degenerate?
  • Modelling segmentation in the fly embryo
  • The role of signalling in the control of single cell phenotypic variabilities during pattern formation in development
  • Discuss the contribution of genetics to our understanding of the cell cycle, and vice versa
  • Common fragile sites : What are they and are they of any biological significance?
  • Discuss spindle positioning mechanisms in vertebrate model systems : Comment on how spindle mispositioning may contribute to carcinogenesis