Draviam Laboratory
Viji M. Draviam PhD
Cancer Research UK Career Development Fellow
Department of Genetics, University of Cambridge, Cambridge CB2 3EHLab Phone No.: +44-1223-333977
Senior Fellow, Wolfson College, Cambridge CB3 9BB
Research Overview
We study the molecular process of chromosome segregation and the consequence of segregation defects in cells and tisssues. Through this research, we aim to understand the molecular pathogenesis of aneuploidy (irregular chromosome numbers) in aggressive cancers.During mitosis, microtubules capture chromosomes and impart pulling forces to segregate them into two equal sets. The onset of chromosome segregation is robustly paused until the correct attachment of all chromosomes to microtubules is complete. How is this robust pause triggered and sustained in the presence of even a single unattached chromosome and what relieves the pause signal are all poorly understood. We investigate the regulation and role of proteins thare required to attach chromosomes to microtubules and to detect and correct defective attachments. Basic molecular understanding of the segregation process is expected to provide key insights into molecular lesions that are prone to promote aneuploidy in tumours.
To study the dynamic changes during chromosome segregation and cell division, we extract both single-cell and population metrics on temporal and mechanical events using live-cell imaging tools. We also employ high-throughput functional genomics and proteomics techniques to identify new regulators of segregation. Our studies use human cancer cell lines and normal mesenchymal stem cells. Visit ongoing research projects for more information.
**Positions Open**
PhD and Post-doctoral opportunities are open. For more information write to:
Funding Support
The Issac Newton Trust
