Examples of dissertation titles offered 2016
- Bacterial persisters: molecular mechanisms and clinical management
- Can we assign a function to 80% of the DNA in the human genome?
- The biology of CRISPR/CAS systems and their uses in eukaryotic genome engineering
- How can genomic data be used to understand cancer evolution and to assist with cancer therapy?
- How does a cell make a decision to divide – or stop dividing?
- How have bdelloid rotifers avoided sex for so long?
- Discuss the concepts presented in C H Waddington’s 1942 paper in Nature ‘Canalisation of development and the inheritance of acquired characteristics’
- Transgenerational epigenetic inheritance in mammals - fact or fiction?
- Many human cancers are aneuploid. Yet aneuploidy has detrimental effects on human development and has been shown to reduce cellular fitness : Consider this conundrum
- Why do endosymbiotic bacteria have small genomes?
- Cell and gene therapy – the future of human monogenic disorders
- Have regulatory changes been more important for the evolution and divergence of species than changes in protein coding sequence?
- Discuss recent developments in the mechanistic understanding of cell size control
Examples of dissertation titles offered 2015
- Human (especially female) meiosis appears to be extraordinarily error-prone. What progress has been made in understanding this genetic problem?
- To what extent can evolution be predicted?
- Discuss the proposition that we can assign a function to 80% of the DNA in the human genome
- Telomeropathies: Consider the contribution of telomere maintenance mechanisms to inherited genetic disease
- The biology of Crispr/Cas systems and their uses in eukaryotic genome engineering
- How can genomic data be used to understand cancer evolution and to assist with cancer therapy?
- Transgenerational epigenetic inheritance in mammals - fact or fiction?
- How much can we learn about essential genes from RNAi screens in worm and fly?
- Discuss the origin and biological significance of horizontal gene transfer events in higher plants
- Why do endosymbiotic bacteria have small genomes?
- How does a cell make a decision to divide or stop dividing?
- What has experimental evolution taught us about how new species arise?
- Discuss the limitations and potential of recent developments in haploid cell genetics