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Examples of recent BBS Dissertation titles

Examples of BBS dissertation titles 2016/7

  • Discuss the molecular mechanisms underpinning bacterial persistence in the face of antibiotic treatment. What problems does this provide for clinical management and what possible solutions have been explored?
  • How can genome sequence data be used to understand influenza evolution?
  • Human (especially female) meiosis is extraordinarily error-prone. What progress has been made in understanding the molecular basis for this genetic problem?
  • Identification of functional variants in cancer genomes
  • What has experimental evolution taught us about how new species develop?
  • Innate immunity pathways in invertebrates
  • Can the bacterial endosymbiont Wolbachia eliminate  vector-borne disease?
  • What are common fragile sites, and do they have any biological significance?
  • Dosage compensation of genes on the mammalian X chromosome: why and how?
  • What does the assembly of embryonic stem cells into tissues and organs in culture say about the development of an organism?
  • Control of transposable elements in vertebrates
  • Complex architecture of ciliate genomes
  • Does our modern understanding of epigenetics challenge the tenets of neo-Darwinism?

Examples of BBS dissertation titles 2015/6

  • Bacterial persisters: molecular mechanisms and clinical management
  • Can we assign a function to 80% of the DNA in the human genome?
  • The biology of CRISPR/CAS systems and their uses in eukaryotic genome engineering
  • How can genomic data be used to understand cancer evolution and to assist with cancer therapy?
  • How does a cell make a decision to divide – or stop dividing?
  • How have bdelloid rotifers avoided sex for so long?
  • Discuss the concepts presented in C H Waddington’s 1942 paper in Nature ‘Canalisation of development and the inheritance of acquired characteristics’
  • Transgenerational epigenetic inheritance in mammals - fact or fiction?
  • Many human cancers are aneuploid. Yet aneuploidy has detrimental effects on human development and has been shown to reduce cellular fitness : Consider this conundrum
  • Why do endosymbiotic bacteria have small genomes?
  • Cell and gene therapy – the future of human monogenic disorders
  • Have regulatory changes been more important for the evolution and divergence of species than changes in protein coding sequence?
  • Discuss recent developments in the mechanistic understanding of cell size control