Examples of BBS dissertation titles 2016/7
- Discuss the molecular mechanisms underpinning bacterial persistence in the face of antibiotic treatment. What problems does this provide for clinical management and what possible solutions have been explored?
- How can genome sequence data be used to understand influenza evolution?
- Human (especially female) meiosis is extraordinarily error-prone. What progress has been made in understanding the molecular basis for this genetic problem?
- Identification of functional variants in cancer genomes
- What has experimental evolution taught us about how new species develop?
- Innate immunity pathways in invertebrates
- Can the bacterial endosymbiont Wolbachia eliminate vector-borne disease?
- What are common fragile sites, and do they have any biological significance?
- Dosage compensation of genes on the mammalian X chromosome: why and how?
- What does the assembly of embryonic stem cells into tissues and organs in culture say about the development of an organism?
- Control of transposable elements in vertebrates
- Complex architecture of ciliate genomes
- Does our modern understanding of epigenetics challenge the tenets of neo-Darwinism?
Examples of BBS dissertation titles 2015/6
- Bacterial persisters: molecular mechanisms and clinical management
- Can we assign a function to 80% of the DNA in the human genome?
- The biology of CRISPR/CAS systems and their uses in eukaryotic genome engineering
- How can genomic data be used to understand cancer evolution and to assist with cancer therapy?
- How does a cell make a decision to divide – or stop dividing?
- How have bdelloid rotifers avoided sex for so long?
- Discuss the concepts presented in C H Waddington’s 1942 paper in Nature ‘Canalisation of development and the inheritance of acquired characteristics’
- Transgenerational epigenetic inheritance in mammals - fact or fiction?
- Many human cancers are aneuploid. Yet aneuploidy has detrimental effects on human development and has been shown to reduce cellular fitness : Consider this conundrum
- Why do endosymbiotic bacteria have small genomes?
- Cell and gene therapy – the future of human monogenic disorders
- Have regulatory changes been more important for the evolution and divergence of species than changes in protein coding sequence?
- Discuss recent developments in the mechanistic understanding of cell size control
