The image displayed on our home page demonstrates how centrioles fail to be converted into mature mothers when scaffolding protein Ana1 is missing from Drosophila testes. Left, Oregon-R; Right, Ana1 mutant.
The paper in which this research was discussed is:
Fu et al (2016) Conserved molecular interactions in centriole-to-centrosome conversion. Nature Cell Biology 18: 87-99
The findings were recently discussed in Strzyz (2016) : Centriole maturation to motherhood. Nature Reviews Molecular Cell Biology 17 : 4
The image below shows the newborn centriole converted into duplication-competent mother through a cascade of protein interactions, controlled both in time and space.
The research was undertaken in the Glover Lab