Postdoctoral Research Associate: Jiggins Group
My research focuses on small RNA pathways, which are found in most animals and plants, and function in antiviral defence, gene regulation and genome stability. I am interested in how different these pathways are between species, and how these differences have evolved. In particular, I am interested in how coevolution between hosts and pathogens has driven changes in small RNA pathways.
Lewis SH, Webster CL, Salmela H, Obbard DJ (2016) Repeated duplication of Argonaute2 is associated with strong selection and testis specialization in Drosophila Genetics Early Online
Lewis SH, Salmela H & Obbard, DJ (2016) Duplication and diversification of Dipteran Argonaute genes, and the evolutionary divergence of Piwi and Aubergine Genome Biology and Evolution 8:507-518
Lewis SH (2016) The evolution of Dipteran Argonaute genes through duplication, selection and functional specialisation PhD Thesis, University of Edinburgh
Webster CL, Longdon B, Lewis SH, Obbard DJ (2016) Twenty five new viruses associated with the Drosophilidae (Diptera) Evolutionary Bioinformatics Suppl. 2 13-25
Lewis SH & Obbard DJ (2014) Recent insights into the evolution of innate viral sensing in Animals Current Opinion in Microbiology 20:170-175
Schnettler E, Tykalova H, Watson M, Sharma M, Sterken MG, Obbard DJ, Lewis SH, et al., Fazakerley JK, Kohl A (2014) Induction and suppression of tick cell antiviral RNAi responses by tick-borne flaviviruses Nucleic Acids Research 42:9436-9446