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Department of Genetics

 

Biography

Marisa studied biochemistry at the University of Buenos Aires, obtained an MSc at the Weizmann Institute of Science followed by her PhD in Biological Chemistry under the supervision of Prof Alex Levitzki, at the Hebrew University of Jerusalem. She undertook postdoctoral studies at the Scripps Research Institute with Prof Steven Reed as an EMBO and HFSP fellow. She started her group at the Department of Genetics in 2001 with a university lectureship.

Research Interests

By combining genetics, biochemistry and live cell imaging. her group explores the molecular mechanisms at the interface between cell cycle controls, mitotic spindle morphogenesis and cell polarity in the context of cells dividing asymmetrically. These mechanisms govern accurate spindle position and chromosomal segregation on the basis of a programme that couples spindle pole age with differential fate. Importantly, this programme exhibits remarkable correspondence between unicellular models such as budding yeast and animal stem cells.

Research Group Links

Segal Group

Publications

Key publications: 

Geymonat M, Peng Q, Guo Z, Yu Z, Unruh JR, Jaspersen SL, Segal M. (2020) Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase. Elife. 9:e59222.  

Geymonat M, Segal M. (2017) Intrinsic and extrinsic determinants linking spindle pole fate, spindle polarity, and asymmetric cell division in the budding yeast S. cerevisiae. Results Probl Cell Differ 61:49-82.  

Juanes MA, Twyman H, Tunnacliffe E, Guo Z, ten Hoopen R and Segal M (2013) Spindle pole body history intrinsically links pole identity with asymmetric fate in budding yeast. Curr Biol 23: 1310-1319.  

ten Hoopen R, Cepeda-García C, Fernández-Arruti R, Juanes MA, Delgehyr N and Segal M (2012) Mechanism for astral microtubule capture by cortical Bud6p priming spindle polarity in S. cerevisiae. Curr Biol 22: 1075-1083 [Also see Curr Biol 22: R496-R499].

Cepeda-García C, Delgehyr N, Juanes Ortiz MA, ten Hoopen R, Zhiteneva A and Segal M (2010) Actin-mediated delivery of astral microtubules instructs Kar9p asymmetric loading to the bud-ward spindle pole. Mol Biol Cell 21: 2685-2695

Full Publication List

PubMed

University Senior Lecturer
Cell Cycle Control of Spindle Morphogenesis in S. cerevisiae
Dr Marisa  Segal
Email address: 
Department of Genetics,
University of Cambridge,
Downing Street,
Cambridge CB2 3EH,
United Kingdom
Takes PhD students

Affiliations