Projects

In a “normal” year the Department offers the choice of “wet” or “dry” projects, which are undertaken in the Lent Term. In 2020/21, due to the COVID pandemic, all projects used dry, computational, research approaches.

Examples of project titles offered 2019/20

• Variable methylation & genomic regulatory context - A machine learning approach.
• The role of DMNT3c in methylation of metastable epialleles in somatic cells.
• Homology Directed Repair-mediated Gene Knock-ins.
• Do E. coli persister cells need RecA to recover from quinolone treatment?
• The role of E. coli RecA in bacterial persistence against quinolone antibiotics.
• Control of Protein Synthesis during Stem Cell Self-Renewal and Differentiation.
• Principal Component Analysis of Population Admixture.
• Effect of Phosphorylation of Ser1213 on TOP2A Localization.
• Systematic analysis of novel (or small) proteins encoded by ORFs embedded in known human proteins.
• Using a phylogenomics approach to understand the evolution of petal patterning.
• Use of a Developmental Time Course to Probe the Establishment and Maintenance of Variable DNA Methylation at Transposable Elements.
• Investigating a novel mechanism in C.Elegans inv Parp-1 and Tnks-2.
• Investigating competency in neural mesodermal progenitors of zebrafish.
• Why is genetic diversity in tetrapods predicted by their life history?

Examples of project titles offered 2018/19

• Integrating ancient African Y-chromosome lineages into present-day phylogenies.
• Topoisomerase II depletion by the auxin-inducible degron system in human cells.
• Mammalian epigenetic control: chromosome architecture and topology in vivo – new insights from genomic imprinting.
• Dissecting Ras inhibition by a novel class of Ras-interacting proteins - a synthetic approach.
• CRISPR-mediated deletion of transposable elements.
• How does an innate immune system recognize a pathogen that is very similar to the host?
• Mechanisms regulating genomic stability during germline development.
• Examine the role of polymerase gamma(tam) in mitochondrial DNA replication and elimination.
• Functional circuitry of odour discrimination in Drosophila larvae.
• Comparative analysis of cancer gene expression data.
• Genetic basis of bullseye pattern formation in Hibiscus flowers.
• Screening for genes that regulate axonal endoplasmic reticulum structure.
• Analysing single cell learning and behaviour with machine learning approaches.
• Drosophila nicotinic acetylcholine receptors.
• Exploring population turnover using evolutionary genetic simulation.
• Systems-level quantitative analyses of spindle pole asymmetric fate.
• The role of centrosome anchoring and release in Drosophila dorsal-ventral axis formation.
• A New Approach to the Treatment of UTIs.
• Why does life history predict genomic diversity?