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Department of Genetics

 
Joseph Baxter microscope 590

Projects

In a “normal” year the Department offers the choice of “wet” or “dry” projects, which are undertaken in the Lent Term. In 2020/21, due to the COVID pandemic, all projects used dry, computational, research approaches.

Examples of project titles offered 2019/20

  • Variable methylation & genomic regulatory context - A machine learning approach.
  • The role of DMNT3c in methylation of metastable epialleles in somatic cells.
  • Homology Directed Repair-mediated Gene Knock-ins.
  • Do E. coli persister cells need RecA to recover from quinolone treatment?
  • The role of E. coli RecA in bacterial persistence against quinolone antibiotics.
  • Control of Protein Synthesis during Stem Cell Self-Renewal and Differentiation.
  • Principal Component Analysis of Population Admixture.
  • Effect of Phosphorylation of Ser1213 on TOP2A Localization.
  • Systematic analysis of novel (or small) proteins encoded by ORFs embedded in known human proteins.
  • Using a phylogenomics approach to understand the evolution of petal patterning.
  • Use of a Developmental Time Course to Probe the Establishment and Maintenance of Variable DNA Methylation at Transposable Elements.
  • Investigating a novel mechanism in C.Elegans inv Parp-1 and Tnks-2.
  • Investigating competency in neural mesodermal progenitors of zebrafish.
  • Why is genetic diversity in tetrapods predicted by their life history?

 

Examples of project titles offered 2018/19

  • Integrating ancient African Y-chromosome lineages into present-day phylogenies.
  • Topoisomerase II depletion by the auxin-inducible degron system in human cells.
  • Mammalian epigenetic control: chromosome architecture and topology in vivo – new insights from genomic imprinting.
  • Dissecting Ras inhibition by a novel class of Ras-interacting proteins - a synthetic approach.
  • CRISPR-mediated deletion of transposable elements.
  • How does an innate immune system recognize a pathogen that is very similar to the host?
  • Mechanisms regulating genomic stability during germline development.
  • Examine the role of polymerase gamma(tam) in mitochondrial DNA replication and elimination.
  • Functional circuitry of odour discrimination in Drosophila larvae.
  • Comparative analysis of cancer gene expression data.
  • Genetic basis of bullseye pattern formation in Hibiscus flowers.
  • Screening for genes that regulate axonal endoplasmic reticulum structure.
  • Analysing single cell learning and behaviour with machine learning approaches.
  • Drosophila nicotinic acetylcholine receptors.
  • Exploring population turnover using evolutionary genetic simulation.
  • Systems-level quantitative analyses of spindle pole asymmetric fate.
  • The role of centrosome anchoring and release in Drosophila dorsal-ventral axis formation.
  • A New Approach to the Treatment of UTIs.
  • Why does life history predict genomic diversity?