Projects
In a “normal” year the Department offers the choice of “wet” or “dry” projects, which are undertaken in the Lent Term. In 2020/21, due to the COVID pandemic, all projects used dry, computational, research approaches.
Examples of project titles offered 2019/20
- Variable methylation & genomic regulatory context - A machine learning approach.
- The role of DMNT3c in methylation of metastable epialleles in somatic cells.
- Homology Directed Repair-mediated Gene Knock-ins.
- Do E. coli persister cells need RecA to recover from quinolone treatment?
- The role of E. coli RecA in bacterial persistence against quinolone antibiotics.
- Control of Protein Synthesis during Stem Cell Self-Renewal and Differentiation.
- Principal Component Analysis of Population Admixture.
- Effect of Phosphorylation of Ser1213 on TOP2A Localization.
- Systematic analysis of novel (or small) proteins encoded by ORFs embedded in known human proteins.
- Using a phylogenomics approach to understand the evolution of petal patterning.
- Use of a Developmental Time Course to Probe the Establishment and Maintenance of Variable DNA Methylation at Transposable Elements.
- Investigating a novel mechanism in C.Elegans inv Parp-1 and Tnks-2.
- Investigating competency in neural mesodermal progenitors of zebrafish.
- Why is genetic diversity in tetrapods predicted by their life history?
Examples of project titles offered 2018/19
- Integrating ancient African Y-chromosome lineages into present-day phylogenies.
- Topoisomerase II depletion by the auxin-inducible degron system in human cells.
- Mammalian epigenetic control: chromosome architecture and topology in vivo – new insights from genomic imprinting.
- Dissecting Ras inhibition by a novel class of Ras-interacting proteins - a synthetic approach.
- CRISPR-mediated deletion of transposable elements.
- How does an innate immune system recognize a pathogen that is very similar to the host?
- Mechanisms regulating genomic stability during germline development.
- Examine the role of polymerase gamma(tam) in mitochondrial DNA replication and elimination.
- Functional circuitry of odour discrimination in Drosophila larvae.
- Comparative analysis of cancer gene expression data.
- Genetic basis of bullseye pattern formation in Hibiscus flowers.
- Screening for genes that regulate axonal endoplasmic reticulum structure.
- Analysing single cell learning and behaviour with machine learning approaches.
- Drosophila nicotinic acetylcholine receptors.
- Exploring population turnover using evolutionary genetic simulation.
- Systems-level quantitative analyses of spindle pole asymmetric fate.
- The role of centrosome anchoring and release in Drosophila dorsal-ventral axis formation.
- A New Approach to the Treatment of UTIs.
- Why does life history predict genomic diversity?
