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Seminar - George Gentsch : Pioneer factors predetermine cell fate decisions by priming the response to inductive signals

When Jul 09, 2018
from 10:00 AM to 11:00 AM
Where Biffen Lecture Theatre, underneath Dept of Genetics
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We have the pleasure of George Gentsch presenting a seminar on 09 July at 10:00 in the Biffen Lecture Theatre.

The title of his talk is "Pioneer factors predetermine cell fate decisions by priming the response to inductive signals"

Abstract

Embryonic development yields myriad cell types with only a handful of inductive signals. Thus, pre-acquired properties (‘competence’) of the signal-receiving cell must determine how signals are interpreted by virtue of activating cell type-specific genes. In my talk, I show the role of maternally controlled chromatin in specifying first competence in the frog Xenopus tropicalis that, like most multicellular organisms, initiates development with a transcriptionally silent genome. I identified the earliest active regulatory DNA sequences, and inferred from them the critical activators of the zygotic genome. Of these, I showed that the sequence-specific pioneering activity of the maternal pluripotency factors Pou5f3 and Sox3 initiates extensive chromatin remodelling to predetermine competence for germ layer formation. I uncover important developmental principles strongly impacting our understanding of tissue engineering and tumorigenesis.