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Departmental Seminar - Chris Illingworth : Viral evolution on sub-phylogenetic timescales

When Feb 15, 2018
from 02:00 PM to 03:00 PM
Where Genetics Part II Room
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15th February 2018  – Part II Room, 2pm

Title: Viral evolution on sub-phylogenetic timescales

Dr Chris Illingworth, Department of Genetics

Abstract:
Genome sequencing has transformed our understanding of pathogen evolution. Many pathogens evolve rapidly, leaving behind genomic signatures which, when correctly understood, provide valuable information about pathogen spread and adaptation.  However, events such as within-host viral evolution and transmission pose a challenge for statistical analysis; few genetic changes fix in the population, such that there is little information available for phylogenetic methods to work on.  Here I describe how population genetic approaches can be combined with time-resolved sequence data to generate valuable insights into pathogen evolution.   By means of example I discuss the cases of within-host reassortment in the influenza virus and of strain specific immunity in the mouse malaria parasite Plasmodium chaubaudi.