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Departmental Seminar - Nick Proudfoot : Defining transcription units across the human genome

When Nov 03, 2016
from 02:00 PM to 03:00 PM
Where Biffen Lecture Theatre, underneath Dept of Genetics
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Professor Nick Proudfoot from Sir William Dunn School of Pathology, University of Oxford will be speaking and the title of the talk is,

''Defining transcription units across the human genome''

The dramatic achievement of sequencing the whole human genome has been tempered by the subsequent realisation that the human transcriptome is far more complex than initially anticipated; far from any clear understanding of how and why it is made. My lab has focused on the basic mechanism of transcriptional termination and associated RNA 3’ end processing by the major RNA polymerase II (Pol II) that is responsible for the synthesis of all pre messenger RNA and most non coding RNAs. We have uncovered a surprising diversity of termination mechanisms using gene specific analyses. We are now applying new native elongating transcription (NET) sequencing strategies to define all Pol II transcription units (especially mammalian NET-seq). Using this technology we are uncovering unanticipated mechanistic cross talk between the basic transcription process and associated pre-mRNA and long non coding RNA processing.

Host: Michaela Frye