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BBSRC-DTP Targeted Studentships available in the Dept of Genetics - NB Deadline extended to 10 January

last modified Dec 04, 2018 10:31 AM

The Department of Genetics is inviting applications for a number of BBSRC-DTP Targeted Studentships, to start in October 2019

THE APPLICATION DEADLINE HAS BEEN EXTENDED TO 10 JANUARY 2019. This is updated information as of 4 Dec 2018

University of Cambridge Graduate applications - Begin at:

Projects offered

Dr Christine Farr: Investigating the hypersensitivity of the core centromere to topoisomerase 2 cleavage

The centromere is essential for stable genome inheritance, a fundamental requirement for the viability of cells and organisms. An unusual and highly conserved feature of the centromere locus is the presence of discrete sites hypersensitive to cleavage by the enzyme topoisomerase 2 (TOP2). This project will use chicken DT40 cells to investigate key aspects of the centromere that may generate unusual secondary structures recognised by TOP2: CENP-A chromatin and DNA replication fork progression. Our study will apply cutting edge molecular and cell biology approaches to dissect the contribution of TOP2 at the eukaryotic centromere, providing molecular insights into this epigenetically-defined chromosomal locus.

>> Lab web page 

Dr. Felipe Karam Teixeira : Mechanisms controlling germline stem cell behaviour and sheltering the germline genome

We study the development of the germline, the immortal cell lineage that provides the continuity of life. Using Drosophila as a model system, we combine developmental, genetics, high-throughput sequencing analyses (small RNA-seq, RNA-seq, Ribo-seq), and computational methods to build a systematic and unbiased understanding of different aspects governing germline biology in vivo. In particular, we are interested in understanding how germline stem cells control their self-renewal, growth, and differentiation capacities throughout life (Sanchez et al, 2016 - Cell Stem Cell), as well as in dissecting the mechanisms protecting the germline genome against selfish DNA modules such as transposable elements (Malone et al, 2015 - Curr Opin Genet Dev; Teixeira et al, 2017 - Nature). PhD projects are available in any of these areas, and involve both experimental and computational approaches.

>> Lab website

Prof Steve Russell: Genome biology of Drosophila Sox transcription factors

Sox domain proteins are highly conserved transcriptional regulators involved in many aspects of metazoan development. In all animals where they have been studied, Group B Sox proteins act redundantly to control key aspects of neural cell specification and differentiation with closely related transcription factors are expressed in the same cells at the same time. Understanding how functional redundancy operates at the level of the genome and has been maintained over 500 My of metazoan evolution, is an intriguing question in genome biology. Given the key role Group B Sox proteins play in mammalian embryonic and induced pluripotent stem cells, the question has considerable relevance to basic research in regenerative medicine. As well as CNS development, in all insects examined to date a Dichaete-class Sox protein has a role in early development with conserved functions during segmentation. Using genomic, genetic and developmental biology approaches we are exploring the redundancy exhibited by Sox genes at the genomic and phenotypic levels, to understand how highly related transcription factors show unique and shared binding events, and how Sox proteins interact with partners to direct transcriptional regulation.

>> Lab web page

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