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Department of Genetics

 

Biography

Professor David Glover FRS FRSE is a former Balfour Professor of Genetics at Cambridge University and currently Wellcome Investigator in the Department of Genetics at the University of Cambridge and Fellow of Fitzwilliam College, Cambridge. He serves as the first editor-in-chief of the open-access journal Open Biology published by the Royal Society.

Professor Glover moved to the University of Cambridge to become the 6th Arthur Balfour Professor of Genetics and Head of Department. In Cambridge he discovered the second main Aurora B kinase required for cells to progress through metaphase and used genetic approaches to identify and demonstrate the roles of the Greatwall kinase in inhibiting protein phosphase 2A during mitotic entry and progression. Over the past decade he has uncovered the major steps of centriole duplication by demonstrating that Polo-like-kinase 4 (Plk4) is its master regulator; Plk4 expression can drive the de novo formation of centrioles in unfertilised Drosophila eggs. In searching for Plk4's partners, his group identified Asterless (Cep152 in human cells) as required for bringing Plk4 to centrioles and an F-box protein, Slimb – a component of the SCF ubiquitin protein ligase, as responsible for targeting excess Plk4 for destruction. They showed that Plk4 phosphorylates the centriole protein Ana2/STIL to enable it to bind the "cartwheel protein" Sas6 and thus initiate procentriole formation, the first step of centriole duplication.

Research Interests

Glover's group are now studying the consequences of supernumerary centrosomes in a variety of mammalian tissues and their consequences for the balance of cell proliferation and differentiation in the skin and pancreas.

Research Group Links

https://www.gen.cam.ac.uk/research-groups/research-groups/glover

https://dmgweb.gen.cam.ac.uk

 

Publications

Key publications: 

 

Full Publication List

PubMed

Google Scholar

‪David M Glover‬ - ‪Google Scholar‬

Director of Research
Research Professor of Biology and Biological Engineering, CalTech
Professor David  Glover
Areas of Interest: 
Regulation of Mitosis and Meiosis
Email address: 
Department of Genetics,
University of Cambridge,
Downing Street,
Cambridge CB2 3EH,
United Kingdom
Office phone: 
+44 (0)1223 333986 [Lab Manager]

Affiliations