Postdoc [Marie Sklodowska-Curie Fellow] : O'Kane Group
Neuroscience
Developmental Biology
Genetics
University of Cambridge,
Downing Street,
Cambridge CB2 3EH,
United Kingdom
Research Interests
In neurons, endoplasmic reticulum (ER) is not only found in the cell body, but also extends into dendrites and axonal presynaptic terminals. Axonal ER comprises a tubular network of mainly smooth ER, whose function is still poorly understood. In humans, mutations of several axonal ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease.
Using Drosophila as model system, we try to understand the functional consequences of disrupting the axonal ER presence or continuity.
Key Publications
Pérez-Moreno JJ, O'Kane CJ (2019), “GAL4 Drivers Specific for Type Ib and Type Is Motor Neurons in Drosophila” G3 9(2):453-462
Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B (2017), “Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction” J Cell Sci 130(5):950-962
Pérez-Moreno JJ, Bischoff M, Martín-Bermudo MD, Estrada B (2014), “The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.” J Cell Sci 127(14):3162-73