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Postdoc : O'Kane Group Nishani Jeyapalan Dr

Research Associate : O'Kane Group

Department of Genetics,
University of Cambridge,
Downing Street,
Cambridge CB2 3EH,
United Kingdom

Biography:

I completed my PhD under the supervision of Dr Amy Reeve, Dr Chris Morris and Professor Sir Doug Turnbull at the Wellcome Trust Centre for Mitochondrial Research (Newcastle University, UK). I investigated mitochondrial dynamics within dopaminergic (DA) neurons of the nigrostriatal pathway in the substantia nigra, the brain region most affected by Parkinson's Disease, via stem cell cultures and mice models. 

Having a large interest in organelle dynamics involvement in neurodegenerative diseases, I have since started my postdoctoral studies Dr. Cahir O'Kane's Group (University of Cambridge, UK) (2019).  My Postdoc research involves investigating ER organisation and dynamics in Drosophila motor neurons. 

Research Interests

The endoplasmic reticulum (ER) can extend throughout the entire neuron. The function of smooth tubular ER remains poorly understood, especially in-regard to its involvement in neuronal-ER dynamics. Mutations affecting ER shaping hairpin proteins can cause Hereditary Spastic Paraplegic (HSP).
My Research involves identifying the following: 1) new mutant phenotypes that affect neuronal ER organisation, 2) novel ER shaping proteins and 3) regulators of ER distribution & dynamics.