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Dr Juan Jose Perez-Moreno

Dr Juan Jose Perez-Moreno

Postdoc [Marie Sklodowska-Curie Fellow] : O'Kane Group

Neuroscience

Developmental Biology

Genetics

Department of Genetics,
University of Cambridge,
Downing Street,
Cambridge CB2 3EH,
United Kingdom

Research Interests

In neurons, endoplasmic reticulum (ER) is not only found in the cell body, but also extends into dendrites and axonal presynaptic terminals. Axonal ER comprises a tubular network of mainly smooth ER, whose function is still poorly understood. In humans, mutations of several axonal ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease.

Using Drosophila as model system, we try to understand the functional consequences of disrupting the axonal ER presence or continuity.

Key Publications

Pérez-Moreno JJ, Espina-Zambrano AG, García-Calderón CB, Estrada B (2017), “Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction” J Cell Sci 130(5):950-962

Pérez-Moreno JJ, Bischoff M, Martín-Bermudo MD, Estrada B (2014), “The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila.” J Cell Sci 127(14):3162-73